Botox Cosmetic manufactured by Allergan is a simple, FDA -Approved, nonsurgical, treatment that can temporarily smooth moderate to severe frown wrinkle lines. But what happens to Botox in approximately 120 days? Simple answer : Botox wears off . Our office insists on baseline pictures and follow up appointments at 2 weeks and 3 months. If patients continue with treatments on regular basis, most often the skin remodels itself and those wrinkles of motion are even better than their baseline pictures.